Puerarin ameliorates colitis by direct suppression of macrophage M1 polarization in DSS mice
Our data suggest that the pathogenesis of DSS colitis is mediated by host cellular responses to toxic foreign molecules and the gut microbiota, and targeting specific cell populations, such as macrophages, with puerarin holds potential therapeutic value.
Authors
- Wenhui Xu (ORCID: https://orcid.org/0000-0002-9490-0207)
- Yongzheng Wu (ORCID: https://orcid.org/0000-0003-0050-8480)
- Cheng Gu (ORCID: https://orcid.org/0000-0002-2244-6551)
- Lei Wang (ORCID: https://orcid.org/0000-0001-9065-2659)
- Yong Wang (ORCID: https://orcid.org/0000-0001-8366-7887)
- Liang Qiao (ORCID: https://orcid.org/0009-0007-0256-5848)
- Jun Qian (ORCID: https://orcid.org/0000-0003-2333-0355)
- Qian Gao (ORCID: https://orcid.org/0000-0001-8189-6061)
- Qing Tao
- Jing Xu (ORCID: https://orcid.org/0000-0002-2093-0518)
- Yimin Zhu (ORCID: https://orcid.org/0000-0003-2565-3633)
- Yuming Peng (ORCID: https://orcid.org/0009-0002-0159-1220)
- Shiyu Song (ORCID: https://orcid.org/0000-0002-1596-7631)
- Yu Fu (ORCID: https://orcid.org/0000-0001-5009-1754)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Drum Tower Hospital (CN)
- Karamay Central Hospital (CN)
- Karamay Central Hospital of Xinjiang (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1016/j.phymed.2024.156048
- Citations
- 43
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 10.34