Huaier-induced suppression of cancer-associated fibroblasts confers immunotherapeutic sensitivity in triple-negative breast cancer
Our findings demonstrate that Huaier regulates cancer immunity in TNBC by suppressing the transition of CAFs to myoCAFs and emphasize the crucial role of Huaier as an effective adjuvant agent in immunotherapy.
Authors
- Chao Yang (ORCID: https://orcid.org/0000-0002-7023-3577)
- Qifeng Yang (ORCID: https://orcid.org/0000-0003-0576-8513)
- Wenhao Li (ORCID: https://orcid.org/0009-0008-1589-9529)
- Yifei Wang (ORCID: https://orcid.org/0000-0003-2813-1128)
- Chen Li (ORCID: https://orcid.org/0000-0001-6994-1253)
- Xiaolong Wang (ORCID: https://orcid.org/0000-0002-3987-6638)
- Xin Li (ORCID: https://orcid.org/0000-0001-6432-3966)
- Tong Chen (ORCID: https://orcid.org/0000-0002-0250-227X)
- Luyao Xing
Institutions
- Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1016/j.phymed.2024.156051
- Citations
- 12
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 5.10
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province