Combinatory effect of ALA-PDT and itraconazole in the treatment of cutaneous protothecosis
ALA-PDT combined with oral itraconazole can be used to treat cutaneous protothecosis. Accordingly, ALA-PDT can destroy the cell wall and partition structure of P. wickerhamii leading to an inhibitory effect on it in vitro, and the effect is enhanced with the increase of ALA concentration and light dose. Also, the sensitivity of P. wickerhamii to itraconazole is observed increased after ALA-PDT. So our study provides a theoretical basis for the promising treatment against cutaneus protothecosis.
Authors
- Junhao Huang (ORCID: https://orcid.org/0000-0001-9981-9558)
- Sha Lu (ORCID: https://orcid.org/0000-0003-0754-7503)
- Junmin Zhang
- Liyan Xi (ORCID: https://orcid.org/0000-0003-1504-0147)
- Qianling Zhang (ORCID: https://orcid.org/0000-0001-6942-3958)
- Jiahao Li (ORCID: https://orcid.org/0000-0002-4107-7720)
- Li Lin (ORCID: https://orcid.org/0000-0001-6990-9413)
- Wenying Cai
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1016/j.pdpdt.2024.104332
- Citations
- 1
- Primary Topic
- Polyomavirus and related diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.28
Funders
- National Natural Science Foundation of China
- Science and Technology Planning Project of Guangdong Province