Genomic profiling of cell-free DNA from dogs with benign and malignant tumors
Similar to the results observed in the healthy dogs, no copy number aberration (CNA) was detected in the dog with benign lipomas, and the distribution of cfDNA fragment size (FS) closely resembled that of the healthy dogs. However, among the three dogs diagnosed with malignant tumors, two dogs exhibited varying degrees and quantities of CNAs. Compared to the distribution of FS in the healthy dogs, the cancer dogs exhibited a noticeable shift towards shorter lengths. These findings indicated that CNA and FS profiles derived from sWGS data can be used for non-invasive cancer detection in dogs.
Authors
- Fangfang Jiang
- Pan Hu (ORCID: https://orcid.org/0000-0002-8214-6147)
- Helen S. Du (ORCID: https://orcid.org/0000-0002-9721-5213)
- Ningning Yan (ORCID: https://orcid.org/0000-0003-3072-7262)
- Jingshuai Li (ORCID: https://orcid.org/0009-0001-1940-6663)
- Lijuan Zhang (ORCID: https://orcid.org/0009-0001-7156-1759)
- Yunfei Li (ORCID: https://orcid.org/0000-0003-3569-5642)
- Wen‐Feng Liu (ORCID: https://orcid.org/0000-0002-4218-4309)
- Shiyong Li (ORCID: https://orcid.org/0000-0003-0416-526X)
- Mao Mao (ORCID: https://orcid.org/0000-0002-8570-8571)
- Dandan Zhu
Institutions
- Yonsei University (KR)
- TiGenix (Spain) (ES)
- Shanghai Genon Biological Products (China) (CN)
- Shenzhen Maternity and Child Healthcare Hospital (CN)
- Shenzhen Goodix Technology (China) (CN)
- Department of Health of Guangdong Province (CN)
- Yonsei University Health System (KR)
Publication Details
- Journal
- BMC Research Notes
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1186/s13104-024-06932-3
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.29