Increasing power in screening trials by testing control-arm specimens: application to multicancer detection screening
Testing stored specimens in the control arm of screening trials to conduct the IE analysis could substantially increase power to reduce sample size or accelerate trials and could provide particularly strong power gains for MCD tests.
Authors
- Hormuzd A. Katki (ORCID: https://orcid.org/0000-0003-2002-0095)
- Philip C. Prorok (ORCID: https://orcid.org/0000-0002-2126-5847)
- Lori M. Minasian
- Paul F. Pinsky (ORCID: https://orcid.org/0000-0002-0350-3282)
- Philip E. Castle (ORCID: https://orcid.org/0000-0002-6408-5985)
Institutions
- National Institutes of Health (US)
- National Cancer Institute (US)
- Department of Health and Human Services (US)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1093/jnci/djae218
- Citations
- 5
- Primary Topic
- Radiomics and Machine Learning in Medical Imaging
- Type
- article
- Field-Weighted Citation Impact
- 2.02
Funders
- National Institutes of Health