Positronium image of the human brain in vivo
Positronium is abundantly produced within the molecular voids of a patient's body during positron emission tomography (PET). Its properties dynamically respond to the submolecular architecture of the tissue and the partial pressure of oxygen. Current PET systems record only two annihilation photons and cannot provide information about the positronium lifetime. This study presents the in vivo images of positronium lifetime in a human, for a patient with a glioblastoma brain tumor, by using the dedicated Jagiellonian PET system enabling simultaneous detection of annihilation photons and prompt gamma emitted by a radionuclide. The prompt gamma provides information on the time of positronium formation. The photons from positronium annihilation are used to reconstruct the place and time of its decay. In the presented case study, the determined positron and positronium lifetimes in glioblastoma cells are shorter than those in salivary glands and those in healthy brain tissues, indicating that positronium imaging could be used to diagnose disease in vivo.
Authors
- T. Kaplanoglu (ORCID: https://orcid.org/0000-0002-9404-8501)
- D. Kumar (ORCID: https://orcid.org/0000-0002-5577-8931)
- Leszek Królicki (ORCID: https://orcid.org/0000-0002-7117-9621)
- Katarzyna Fronczewska
- Catalina Curceanu (ORCID: https://orcid.org/0000-0002-1990-0127)
- Keyvan Tayefi Ardebili (ORCID: https://orcid.org/0000-0001-8764-1588)
- R. Y. Shopa (ORCID: https://orcid.org/0000-0002-1089-5050)
- M. Skurzok (ORCID: https://orcid.org/0000-0002-4794-5154)
- Jolanta Kunikowska (ORCID: https://orcid.org/0000-0002-7434-6720)
- J. Choiński (ORCID: https://orcid.org/0000-0003-3195-3050)
- W. Migdał (ORCID: https://orcid.org/0000-0003-3382-376X)
- Joanna Mączewska (ORCID: https://orcid.org/0000-0002-3522-8633)
- E. Czerwiński (ORCID: https://orcid.org/0000-0002-5076-3175)
- W. Krzemień (ORCID: https://orcid.org/0000-0002-9546-358X)
- L. Raczyński
- A. Gajos (ORCID: https://orcid.org/0000-0002-7536-6459)
- Małgorzata Kobylecka (ORCID: https://orcid.org/0000-0002-3491-6514)
- G. Korcyl (ORCID: https://orcid.org/0000-0001-6244-7287)
- K. Klimaszewski (ORCID: https://orcid.org/0000-0003-0741-5922)
- Steven D. Bass (ORCID: https://orcid.org/0000-0002-2089-9661)
- Szymon Niedźwiecki (ORCID: https://orcid.org/0000-0002-5953-9479)
- Paweł Moskal (ORCID: https://orcid.org/0000-0002-4229-3548)
- M. Kajetanowicz (ORCID: https://orcid.org/0000-0002-4555-2090)
- M. Silarski (ORCID: https://orcid.org/0000-0003-2206-0963)
- Karol Kubat (ORCID: https://orcid.org/0000-0003-1121-4445)
- Manish Das (ORCID: https://orcid.org/0009-0001-2901-1745)
- Kavya Valsan Eliyan (ORCID: https://orcid.org/0000-0003-1636-3706)
- T. Kozik (ORCID: https://orcid.org/0000-0002-8131-5674)
- Gabriel Moskal (ORCID: https://orcid.org/0000-0002-9628-3564)
- S. Parzych (ORCID: https://orcid.org/0000-0002-3049-2267)
- P. Tanty (ORCID: https://orcid.org/0009-0008-7376-9650)
- Ł. Kapłon (ORCID: https://orcid.org/0000-0002-2203-0425)
- K. Dulski (ORCID: https://orcid.org/0000-0002-4093-8162)
- N. Chug (ORCID: https://orcid.org/0000-0002-6496-0866)
- E. Pérez del Río (ORCID: https://orcid.org/0000-0001-7761-4084)
- K. Kacprzak (ORCID: https://orcid.org/0000-0001-6105-4449)
- Ewa Łucja Stępień (ORCID: https://orcid.org/0000-0003-3589-1715)
- W. Mryka (ORCID: https://orcid.org/0009-0006-7616-8290)
- S. Sharma (ORCID: https://orcid.org/0000-0001-8947-0110)
- Shivani Shivani
- M. Dadgar (ORCID: https://orcid.org/0000-0002-7160-5715)
- Jakub Baran (ORCID: https://orcid.org/0000-0002-4946-3837)
- F. Tayefi
- W. Wiślicki (ORCID: https://orcid.org/0000-0001-5765-6308)
Institutions
- Jagiellonian University (PL)
- Medical University of Warsaw (PL)
- National Centre for Nuclear Research (PL)
- Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Frascati (IT)
- University of Warsaw (PL)
Publication Details
- Journal
- Science Advances
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1126/sciadv.adp2840
- Citations
- 51
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 20.62
Funders
- Strong
- Fundacja na rzecz Nauki Polskiej