Lead-in calorie restriction enhances the weight-lowering efficacy of incretin hormone-based pharmacotherapies in mice
Our findings provide compelling evidence that calorie restriction prior to incretin-based therapy enhances the achievable extent of weight loss, as reflected in a weight loss plateau at a lower level compared to that of treatment without prior calorie reduction. This work suggests that more intensive lifestyle interventions should be considered prior to pharmacological treatment, encouraging further exploration and discussion of the current standard of care.
Authors
- Jonas Petersen (ORCID: https://orcid.org/0000-0002-6219-0271)
- Jens Lund (ORCID: https://orcid.org/0000-0003-2338-6033)
- Christoffer Merrild (ORCID: https://orcid.org/0009-0004-5076-1534)
- Christoffer Clemmensen (ORCID: https://orcid.org/0000-0003-2456-9667)
- Stephanie Holm (ORCID: https://orcid.org/0000-0002-9628-8285)
Institutions
- University of Copenhagen (DK)
- Novo Nordisk Foundation (DK)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1016/j.molmet.2024.102027
- Citations
- 12
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 3.29
Funders
- Danish Diabetes Academy
- Københavns Universitet
- Lundbeckfonden
- Novo Nordisk Fonden