Younger epigenetic age is associated with higher cardiorespiratory fitness in individuals with airflow limitation

We hypothesized that increased cardiorespiratory fitness (CRF) slows down a person's aging, particularly in individuals with chronic airflow limitation (CAL). Participants aged ≥40 years (<i>n</i> = 78) had baseline blood DNA methylation profiled and underwent cardiopulmonary cycle exercise testing at baseline and at three years. Epigenetic clocks were calculated and tested for their association with CRF using linear regression. Differentially methylated genes associated with CRF were identified using a robust linear model. Higher CRF at baseline was associated with lower age acceleration in the epigenetic clocks DNAmAgeSkinBlood (<i>p = 0.016</i>), DNAmGrimAge (<i>p = 0.012</i>), and DNAmGrimAge2 (<i>p = 0.011</i>). These effects were consistent in individuals with CAL (DNAmGrimAge <i>p = 0.009</i> and DNAmGrimAge2 <i>p = 0.007</i>). CRF at three years was associated with baseline DNAmGrimAge (<i>p = 0.015</i>) and DNAmGrimAge2 (<i>p = 0.011</i>). Differentially methylated genes associated with CRF enriched multiple aging-related pathways, including cellular senescence. Enhancing CRF may be one intervention that can slow biological aging and improve health outcomes in chronic respiratory diseases.

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Publication Details

Journal
iScience
Published
2024-09-13
DOI
https://doi.org/10.1016/j.isci.2024.110934
Citations
6
Primary Topic
Birth, Development, and Health
Type
article
Field-Weighted Citation Impact
6.66

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article

Younger epigenetic age is associated with higher cardiorespiratory fitness in individuals with airflow limitation

Ana I. Hernández Cordero, Qing Duan, Jean Bourbeau, Julie L. MacIsaac et al.
6 citations
iScience
Birth, Development, and Health
6.66
article

Younger epigenetic age is associated with higher cardiorespiratory fitness in individuals with airflow limitation

Ana I. Hernández Cordero, Qing Duan, Jean Bourbeau, Julie L. MacIsaac, Graeme J. Koelwyn, Michael K. Stickland, Don D. Sin, Chen Xi Yang, Dany Doiron, Amirthagowri Ambalavanan, Carli M. Peters, Michael S. Kobor, Dennis Jensen, Wan C. Tan, Gregory J. Fonseca, Xuan Li, Janice M. Leung
article en
6 citations

Abstract

We hypothesized that increased cardiorespiratory fitness (CRF) slows down a person's aging, particularly in individuals with chronic airflow limitation (CAL). Participants aged ≥40 years (<i>n</i> = 78) had baseline blood DNA methylation profiled and underwent cardiopulmonary cycle exercise testing at baseline and at three years. Epigenetic clocks were calculated and tested for their association with CRF using linear regression. Differentially methylated genes associated with CRF were identified using a robust linear model. Higher CRF at baseline was associated with lower age acceleration in the epigenetic clocks DNAmAgeSkinBlood (<i>p = 0.016</i>), DNAmGrimAge (<i>p = 0.012</i>), and DNAmGrimAge2 (<i>p = 0.011</i>). These effects were consistent in individuals with CAL (DNAmGrimAge <i>p = 0.009</i> and DNAmGrimAge2 <i>p = 0.007</i>). CRF at three years was associated with baseline DNAmGrimAge (<i>p = 0.015</i>) and DNAmGrimAge2 (<i>p = 0.011</i>). Differentially methylated genes associated with CRF enriched multiple aging-related pathways, including cellular senescence. Enhancing CRF may be one intervention that can slow biological aging and improve health outcomes in chronic respiratory diseases.

iScienceVol. 27(10)
University of British Columbia (CA), University of Alberta (CA), Simon Fraser University (CA), Queen's University (CA), McGill University Health Centre (CA), St. Paul's Hospital (CA), McGill University (CA)
AstraZeneca, GlaxoSmithKline, AstraZeneca Canada, Canada Research Chairs, Reseau canadien de recherche respiratoire, Canadian Institutes of Health Research, Institute of Circulatory and Respiratory Health
Openalex Percentile: Top 4%
Birth, Development, and Health
6.66
DOIOpen Access PDFOpenAlex
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