Leukocyte cell-derived chemotaxin 2 (LECT2) regulates liver ischemia–reperfusion injury
Elevated LECT2 levels during hepatic IRI increased liver damage. Genetic knockout or shRNA-mediated knockdown of <i>Lect2</i> reduced liver damage, indicating its therapeutic potential. AAV-mediated Lect2-shRNA delivery mitigated hepatic IRI, offering a potential new treatment strategy to enhance clinical outcomes for patients undergoing liver-related surgeries or trauma.
Authors
- Zhimin Liu (ORCID: https://orcid.org/0000-0002-9333-8101)
- Weijie Zhou (ORCID: https://orcid.org/0000-0002-0021-9454)
- Fengyong Liu (ORCID: https://orcid.org/0000-0002-4474-1308)
- Yuan Xie (ORCID: https://orcid.org/0000-0003-4563-4683)
- Fu-Zhen Lin
- Meng-Qi Dong
- Guangyu Zhang (ORCID: https://orcid.org/0000-0003-1057-7746)
- Lin Yuan (ORCID: https://orcid.org/0000-0003-3283-9495)
- Zhihao Huang
- Xue-Wen Zhao
- Zhi-Liang Tang
Institutions
- Chinese PLA General Hospital (CN)
- The First People's Hospital of Zhaoqing (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Liver Research
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.livres.2024.09.004
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00