A Bayesian reanalysis of the CULPRIT-SHOCK trial
Our Bayesian reanalysis provides intuitive insights by quantifying probabilities of treatment effect sizes, offering further evidence favouring the culprit lesion-only PCI strategy in AMI patients with CS and multivessel disease. The analysis demonstrates a high probability of overall benefit, with a notable chance of achieving a minimally clinically important difference, particularly in specific subgroups. These findings not only support the consideration of culprit lesion-only PCI in certain patient populations but also underscore the need for careful risk-benefit assessment. Furthermore, our hypothesis-generating subgroup analyses, which show varying probabilities of achieving MCID, illuminate promising avenues for future targeted investigations in this critical patient population.
Authors
- Malte Kelm (ORCID: https://orcid.org/0000-0003-0060-1052)
- Christian Jung (ORCID: https://orcid.org/0000-0001-8325-250X)
- Anne Freund (ORCID: https://orcid.org/0000-0002-4999-6238)
- Bernhard Wernly (ORCID: https://orcid.org/0000-0003-4024-0220)
- Maryna Masyuk (ORCID: https://orcid.org/0000-0003-2856-6893)
- Hölger Thiele (ORCID: https://orcid.org/0000-0002-0169-998X)
- Benedikt Schrage (ORCID: https://orcid.org/0000-0001-9041-3922)
- İbrahim Akın (ORCID: https://orcid.org/0000-0002-4387-7115)
- Steffen Schneider (ORCID: https://orcid.org/0000-0001-9375-4861)
- Sabrina Schlesinger (ORCID: https://orcid.org/0000-0003-4244-0832)
- Uwe Zeymer (ORCID: https://orcid.org/0000-0001-7077-283X)
- Steffen Desch (ORCID: https://orcid.org/0000-0002-1349-9969)
- Janine Pöss
Institutions
- University of Mannheim (DE)
- Heidelberg University (DE)
- Paracelsus Medical University (AT)
- University Hospital Heidelberg (DE)
- Düsseldorf University Hospital (DE)
- Stiftung Institut für Herzinfarktforschung (DE)
- Leipzig Heart Institute (DE)
- Krankenhaus Oberndorf (AT)
- German Centre for Cardiovascular Research (DE)
- Klinikum Ludwigshafen (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- Saint John of God Hospital
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- European Heart Journal Acute Cardiovascular Care
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1093/ehjacc/zuae104
- Citations
- 4
- Primary Topic
- Health Systems, Economic Evaluations, Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 4.52