Dual-modality high-resolution microendoscope with adjustable maging depth for in vivo cancer detection

We developed a low-cost dual-modality high-resolution microendoscope, which implemented fluorescence imaging and darkfield reflectance imaging to characterize nuclear atypia and dysregulated angiogenesis for in vivo cancer detection. Cell nuclei and microvasculature located at different depths in tissue epithelium were visualized in high spatial resolution by using a compact fiber-based imaging probe with adjustable imaging depth.