Association of Polygenic Risk Score With Lifetime Risk of Developing Multiple Sclerosis in a Population-Based Birth-Year Cohort
Our results show that the lifetime risk of MS is strongly influenced by genetic factors. Our findings have the potential to support diagnostic certainty in individuals with suspected MS: a high PRS could strengthen a diagnosis, but especially a PRS from the lowest tail of the PRS distribution should be considered a red flag and could prevent misdiagnosing conditions that mimic MS.
Authors
- Marc Hulsman (ORCID: https://orcid.org/0000-0002-9889-3606)
- Bernard M.J. Uitdehaag (ORCID: https://orcid.org/0000-0002-9226-7364)
- Eva M. M. Strijbis (ORCID: https://orcid.org/0000-0001-6705-5864)
- Floor C. Loonstra (ORCID: https://orcid.org/0000-0002-1644-4410)
- Henne Holstege (ORCID: https://orcid.org/0000-0002-7688-3087)
- Sven J. van der Lee (ORCID: https://orcid.org/0000-0003-1606-8643)
- Alex Salazar (ORCID: https://orcid.org/0000-0002-8453-8769)
- Daniel Álvarez Sirvent
- Niccoló Tesi (ORCID: https://orcid.org/0000-0002-1413-5091)
Institutions
- Amsterdam Neuroscience (NL)
Publication Details
- Journal
- Neurology
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1212/wnl.0000000000209663
- Citations
- 5
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.12