The Adverse Effects of Commonly Prescribed Antiseizure Medications in Adults With Newly Diagnosed Focal Epilepsy
Systematic screening for AEs in adults with newly diagnosed focal epilepsy on ASM monotherapy showed that those with comorbid psychiatric conditions report greater AEs overall, irrespective of ASM. Levetiracetam was associated with >3-fold risk of psychiatric AEs and half the risk of experiencing unsteadiness than lamotrigine. Levetiracetam had the highest proportion of discontinuations because of AEs alone, while lamotrigine had the lowest.
Authors
- Sarah Barnard (ORCID: https://orcid.org/0000-0003-0517-2533)
- Andrés M. Kanner (ORCID: https://orcid.org/0000-0003-2857-8034)
- Piero Perucca (ORCID: https://orcid.org/0000-0002-7855-7066)
- Pavel Klein (ORCID: https://orcid.org/0000-0001-7244-3722)
- Jacqueline A. French (ORCID: https://orcid.org/0000-0003-2242-8027)
- Manisha Holmes (ORCID: https://orcid.org/0000-0002-4262-0764)
- Bassel W Abou-Khalil (ORCID: https://orcid.org/0000-0002-6559-1329)
- Barry E. Gidal (ORCID: https://orcid.org/0000-0001-6681-7134)
- Zhibin Chen (ORCID: https://orcid.org/0000-0002-1888-6917)
Institutions
- University of Miami (US)
Publication Details
- Journal
- Neurology
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1212/wnl.0000000000209821
- Citations
- 17
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.55