The influence of the sizes of nanodiamond aggregates in their suspensions on the efficiency of sorption of <sup>90</sup>Y and <sup>177</sup>Lu isotopes for their subsequent use in nuclear medicine
Nanodiamonds (NDs) are promising carriers of radionuclides in radiopharmaceuticals for use in nuclear medicine. In this work, we investigated the influence of the properties of ND suspensions, including the sizes of their aggregates, in aqueous solutions with different pH on their binding of medical isotopes 90Y and 177Lu and found the conditions for obtaining promising conjugates for further in vivo studies. It was shown that sorption is influenced by the composition of the solution, which determines the properties of the ND surface, while the forms of cations of the studied nuclides in the solution do not affect the degree of sorption.
Authors
- В. Л. Садкин
- Boris F. Myasoedov (ORCID: https://orcid.org/0000-0002-1400-0314)
- J. S. Babenya (ORCID: https://orcid.org/0000-0003-1965-5237)
- Е. А. Нестеров (ORCID: https://orcid.org/0000-0001-9138-6700)
- T. Y. Ekatova (ORCID: https://orcid.org/0000-0002-1292-7060)
- С. Е. Винокуров (ORCID: https://orcid.org/0000-0002-1384-1066)
- A. G. Kazakov (ORCID: https://orcid.org/0000-0003-4872-9792)
- А. С. Рогов (ORCID: https://orcid.org/0000-0003-1329-3255)
- I.A. Ushakov (ORCID: https://orcid.org/0000-0002-3821-5176)
- E. S. Stasyuk (ORCID: https://orcid.org/0000-0003-4875-6555)
- V. V. Zukau
- E. Y. Khvorostinin
Institutions
- Russian Academy of Sciences (RU)
- National Research Tomsk State University (RU)
- Tomsk Polytechnic University (RU)
- V.I. Vernadsky Institute of Geochemistry and Analytical Chemistry (RU)
Publication Details
- Journal
- РАДИОХИМИЯ
- Published
- 2024-09-13
- DOI
- https://doi.org/10.31857/s0033831124020093
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00