Nanodiamonds as lutetium-177 carriers for nuclear medicine

The work investigated the sorption of carrier-free 177Lu isolated from neutron-irradiated 176Yb2O3, and with a carrier obtained by irradiation of natLu2O3, by commercial and oxidized nanodiamonds (NDs) of various brands from aqueous solutions to identify among them a promising carrier for further research for the purposes of nuclear medicine. A promising sorbent was found: oxidized NDs of the STP brand (ox-STP); conditions for the rapid sorption of lutetium by it in an amount equivalent to 1.2 GBq of carrier-free 177Lu were determined, which corresponds to the activity used in therapy.

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РАДИОХИМИЯ
Published
2024-09-13
DOI
https://doi.org/10.31857/s0033831124020088
Primary Topic
Diamond and Carbon-based Materials Research
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article
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article

Nanodiamonds as lutetium-177 carriers for nuclear medicine

В. Л. Садкин, Boris F. Myasoedov, J. S. Babenya, Е. А. Нестеров et al.
РАДИОХИМИЯ
Diamond and Carbon-based Materials Research
article

Nanodiamonds as lutetium-177 carriers for nuclear medicine

В. Л. Садкин, Boris F. Myasoedov, J. S. Babenya, Е. А. Нестеров, T. Y. Ekatova, С. Е. Винокуров, A. G. Kazakov, А. С. Рогов, I.A. Ushakov, E. S. Stasyuk, V. V. Zukau, E. Y. Khvorostinin
article en

Abstract

The work investigated the sorption of carrier-free 177Lu isolated from neutron-irradiated 176Yb2O3, and with a carrier obtained by irradiation of natLu2O3, by commercial and oxidized nanodiamonds (NDs) of various brands from aqueous solutions to identify among them a promising carrier for further research for the purposes of nuclear medicine. A promising sorbent was found: oxidized NDs of the STP brand (ox-STP); conditions for the rapid sorption of lutetium by it in an amount equivalent to 1.2 GBq of carrier-free 177Lu were determined, which corresponds to the activity used in therapy.

РАДИОХИМИЯVol. 66(2)
Russian Academy of Sciences (RU), National Research Tomsk State University (RU), Tomsk Polytechnic University (RU), V.I. Vernadsky Institute of Geochemistry and Analytical Chemistry (RU)
Openalex Percentile: Top 91%
Diamond and Carbon-based Materials Research
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