TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
Novel individual biomarkers are needed to guide therapeutic decisions for patients with head and neck cancer. We report for the first time, granulomas of TREM2-expressing multinucleated giant macrophages in keratin-rich tumor niches, as a biomarker of favorable prognosis and developed a deep-learning model to automate its quantification on routinely stained pathological slides.
Authors
- Alexandre Sayadi (ORCID: https://orcid.org/0000-0003-4377-9926)
- Pierre Busson (ORCID: https://orcid.org/0000-0003-1027-3400)
- Thomas Walter (ORCID: https://orcid.org/0000-0001-7419-7879)
- Antoine Moya‐Plana (ORCID: https://orcid.org/0000-0003-1260-1762)
- Grégoire Gessain (ORCID: https://orcid.org/0000-0001-6800-0339)
- Charles‐Antoine Dutertre (ORCID: https://orcid.org/0000-0001-7950-3652)
- Nicolas Signolle (ORCID: https://orcid.org/0000-0001-6222-6003)
- Anne Aupérin (ORCID: https://orcid.org/0000-0003-1545-0373)
- Camille Blériot (ORCID: https://orcid.org/0000-0002-4298-2888)
- Daniela Weidner (ORCID: https://orcid.org/0009-0008-6637-5071)
- Philippe Gorphe (ORCID: https://orcid.org/0000-0001-7604-4964)
- Stefan Uderhardt (ORCID: https://orcid.org/0000-0002-2489-2109)
- Antonin Marchais (ORCID: https://orcid.org/0000-0003-0954-8294)
- Jean‐Yves Scoazec (ORCID: https://orcid.org/0000-0003-1604-6823)
- Sumanth Reddy Nakkireddy (ORCID: https://orcid.org/0000-0002-7771-6782)
- Mathilde Bied
- Florent Ginhoux (ORCID: https://orcid.org/0000-0002-2857-7755)
- Kevin Mulder (ORCID: https://orcid.org/0000-0002-1568-6581)
- Daniel Stockholm (ORCID: https://orcid.org/0000-0002-5069-5256)
- Alix Marhic (ORCID: https://orcid.org/0000-0002-9437-0744)
- Quentin Blampey (ORCID: https://orcid.org/0000-0002-3836-2889)
- Joanne Guerlain (ORCID: https://orcid.org/0000-0002-2685-6726)
- Marvin Lerousseau (ORCID: https://orcid.org/0000-0001-6421-708X)
- Odile Casiraghi (ORCID: https://orcid.org/0000-0002-5920-0301)
- Sophie Broutin (ORCID: https://orcid.org/0000-0001-6333-3636)
- Ingrid Breuskin (ORCID: https://orcid.org/0000-0001-9447-2567)
- Marion Classe (ORCID: https://orcid.org/0000-0002-0802-6585)
- Maria Eugénia Marques Da Costa (ORCID: https://orcid.org/0000-0002-1498-603X)
- Farah Sassi (ORCID: https://orcid.org/0000-0003-2078-6795)
- Ahmed-Amine Anzali
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- École Pratique des Hautes Études (FR)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Shanghai Jiao Tong University (CN)
- Université Paris Cité (FR)
- Université Paris Sciences et Lettres (FR)
- Université Paris-Saclay (FR)
- Singapore Immunology Network (SG)
- Jacksonville College (US)
- Institut Gustave Roussy (FR)
- Sanofi (France) (FR)
- Sorbonne Université (FR)
- Institut Necker Enfants Malades (FR)
- Universitätsklinikum Erlangen (DE)
- Sorbonne Paris Cité (FR)
- La Ligue Contre le Cancer (FR)
- SingHealth Duke-NUS Academic Medical Centre (SG)
- CentraleSupélec (FR)
- Centre de Recherche Saint-Antoine (FR)
- Mayo Clinic in Florida (US)
- Médecins Sans Frontières (FR)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-0018
- Citations
- 15
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.61
Funders
- Fondation ARC pour la Recherche sur le Cancer
- Institut National Du Cancer