Fibrosis, biomarkers and liver biopsy in <scp>AAT</scp> deficiency and relation to liver Z protein polymer accumulation
In AATD high BMI, obesity and elevated AST are associated with increased fibrosis. Liver biopsy features are correlated to some serum tests. Serum Z AAT polymer levels could be a future biomarker to detect fibrosis early and is directly correlated to liver Z content.
Authors
- Keith Blomenkamp (ORCID: https://orcid.org/0000-0002-0849-9497)
- David A. Brenner (ORCID: https://orcid.org/0000-0003-2573-525X)
- Zidong Zhang (ORCID: https://orcid.org/0000-0002-1084-9732)
- Jeffrey Teckman (ORCID: https://orcid.org/0000-0002-4870-2621)
- Rosemary Nagy
- Anandini Suri (ORCID: https://orcid.org/0000-0001-6116-2909)
- Keith Burling (ORCID: https://orcid.org/0000-0002-0109-7751)
- Andrew A. Wilson (ORCID: https://orcid.org/0000-0003-3406-9906)
- Brent A. Neuschwander‐Tetri (ORCID: https://orcid.org/0000-0002-8520-7398)
- Danielle Carpenter (ORCID: https://orcid.org/0000-0001-7203-7046)
- Nina Heyer‐Chauhan (ORCID: https://orcid.org/0000-0002-3500-9174)
- Rohit Loomba
- David A. Lomas
Institutions
- Boston University (US)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- University of California San Diego (US)
- University College London (GB)
- Saint Louis University (US)
Publication Details
- Journal
- Liver International
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1111/liv.16094
- Citations
- 7
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.98
Funders
- Alpha-1 Foundation
- Alnylam Pharmaceuticals
- Vertex Pharmaceuticals
- Arrowhead Pharmaceuticals
- Medical Research Council