An epigenome‐wide study of a needs‐based family intervention for offspring of trauma‐exposed mothers in Kosovo
We find evidence that a tailored family-based intervention reduced stress levels in the children (based on cortisol levels), and modified DNA methylation levels at a number of sites across the genome. This study provides some preliminary evidence to suggest the potential for tailored interventions to help break the intergenerational transmission of trauma, however, large studies powered to detect associations at genome-wide significant levels are needed.
Authors
- Peter Fransquet (ORCID: https://orcid.org/0000-0002-3515-0557)
- Vjosa Devaja Xhemaili
- Sebahate Pacolli Krasniqi
- Mimoza Salihu
- Feride Rushiti
- Line Hjort (ORCID: https://orcid.org/0000-0003-4673-4176)
- Selvi Izeti Çarkaxhiu
- Aung Zaw Zaw Phyo (ORCID: https://orcid.org/0000-0002-8834-4072)
- Joanne Ryan (ORCID: https://orcid.org/0000-0002-7039-6325)
- Shr‐Jie Wang (ORCID: https://orcid.org/0000-0003-1644-205X)
- Qëndresa Prapashtica
- Nebahate Zekaj
- Vesa Turjaka
- Sara Helene Kaas‐Petersen
- Dafina Arifaj Limani
Institutions
- University of Copenhagen (DK)
- Deakin University (AU)
- Novo Nordisk Foundation (DK)
- Copenhagen University Hospital (DK)
- Danish Institute against Torture (DK)
- Monash University (AU)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/brb3.70029
- Citations
- 1
- Primary Topic
- Migration, Health and Trauma
- Type
- article
- Field-Weighted Citation Impact
- 0.64
Funders
- Danish Diabetes Academy
- Novo Nordisk
- Novo Nordisk Fonden
- Medical Research Council
- National Health and Medical Research Council