Design considerations for Factorial Adaptive Multi-Arm Multi-Stage (FAST) clinical trials
Motivated by a trial currently under design, our work shows that the FAST category of trial can potentially offer benefits similar to both MAMS and factorial designs; however, the chosen design aspects which can be included in a FAST trial need to be thoroughly explored during the planning phase.
Authors
- Matthew W. Semler (ORCID: https://orcid.org/0000-0002-7664-8263)
- William J. Mack (ORCID: https://orcid.org/0000-0003-0970-2546)
- Todd W. Rice (ORCID: https://orcid.org/0000-0002-7136-5408)
- Hooman Kamel (ORCID: https://orcid.org/0000-0002-5745-0307)
- Akshitkumar M. Mistry (ORCID: https://orcid.org/0000-0002-7918-5153)
- Jordan Elm
- Jonathan Beall (ORCID: https://orcid.org/0000-0003-2135-2606)
- Li Wang (ORCID: https://orcid.org/0000-0002-5205-7290)
Institutions
- University of Southern California (US)
- University of Louisville (US)
- Medical University of South Carolina (US)
- Vanderbilt University (US)
- Cornell University (US)
- Weill Cornell Medicine (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Trials
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1186/s13063-024-08400-6
- Citations
- 2
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 1.42
Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke