Clinico-physiological correlates of Parkinson’s disease from multi-resolution basal ganglia recordings
Parkinson's disease (PD) has been associated with pathological neural activity within the basal ganglia. Herein, we analyzed resting-state single-neuron and local field potential (LFP) activities from people with PD who underwent awake deep brain stimulation surgery of the subthalamic nucleus (STN; n = 125) or globus pallidus internus (GPi; n = 44), and correlated rate-based and oscillatory features with UPDRSIII off-medication subscores. Rate-based single-neuron features did not correlate with PD symptoms. STN single-neuron and LFP low-beta (12-21 Hz) power and burst dynamics showed modest correlations with bradykinesia and rigidity severity, while STN spiketrain theta (4-8 Hz) power correlated modestly with tremor severity. GPi low- and high-beta (21-30 Hz) power and burst dynamics correlated moderately with bradykinesia and axial symptom severity. These findings suggest that elevated single-neuron and LFP oscillations may be linked to symptoms, though modest correlations imply that the pathophysiology of PD may extend beyond resting-state beta oscillations.
Authors
- Miloš R. Popović (ORCID: https://orcid.org/0000-0002-2837-2346)
- William D. Hutchison (ORCID: https://orcid.org/0000-0002-3866-4940)
- Conor Fearon (ORCID: https://orcid.org/0000-0002-8172-6094)
- Luka Milosevic (ORCID: https://orcid.org/0000-0002-4051-5397)
- Prerana Keerthi
- Oliver Flouty (ORCID: https://orcid.org/0000-0001-5990-7297)
- Alfonso A. Fasano (ORCID: https://orcid.org/0000-0001-5346-0180)
- Srdjan Sumarac (ORCID: https://orcid.org/0000-0002-3840-5957)
- Andrés M. Lozano (ORCID: https://orcid.org/0000-0001-8257-3694)
- Mojgan Hodaie (ORCID: https://orcid.org/0000-0001-6278-4929)
- Jinyoung Youn (ORCID: https://orcid.org/0000-0003-3350-5032)
- Suneil Kalia
- Luka Zivkovic
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- University of South Florida (US)
- Toronto Western Hospital (CA)
- Center for Innovation (US)
- Ontario Brain Institute (CA)
Publication Details
- Journal
- npj Parkinson s Disease
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1038/s41531-024-00773-4
- Citations
- 14
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.17
Funders
- Fondation Brain Canada
- Government of Canada
- Azrieli Foundation
- Parkinson Canada
- Health Canada
- Natural Sciences and Engineering Research Council of Canada