Identification of Potential Therapeutics for Infantile Hemangioma via in silico Investigation and in vitro Validation
Our investigation revealed that the pathogenic mechanism underlying IH might be closely associated with the <i>PI3K/AKT/MTOR, RAS/MAPK</i>, and <i>CGMP/PKG</i> signaling pathways. Furthermore, we identified twelve molecular-targeting agents among the predicted drugs that show promise as therapeutic candidates for IH.
Authors
- Zuoliang Qi (ORCID: https://orcid.org/0000-0002-8730-065X)
- Xiaonan Yang (ORCID: https://orcid.org/0000-0002-3353-6982)
- Lu Wei (ORCID: https://orcid.org/0000-0001-5396-4004)
- Ye Zhang (ORCID: https://orcid.org/0000-0003-4157-8696)
- Mengjie Wang (ORCID: https://orcid.org/0000-0003-3469-6010)
- Zhenyu Yang (ORCID: https://orcid.org/0000-0001-6151-8151)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/dddt.s460575
- Citations
- 6
- Primary Topic
- Vascular Malformations and Hemangiomas
- Type
- article
- Field-Weighted Citation Impact
- 3.44