Causal effects and metabolites mediators between immune cell and risk of colorectal cancer: a Mendelian randomization study
This study delineates a complex network involving immune cells, metabolites, and CRC, suggesting a multifaceted pathophysiological interaction. The identified causal links and mediation pathways underscore potential therapeutic targets, providing a foundation for interventions aimed at modulating immune responses to manage CRC.
Authors
- Jie Kan
- Donglin Zhang (ORCID: https://orcid.org/0000-0002-1203-991X)
- Xueping Chen (ORCID: https://orcid.org/0000-0003-0499-0972)
- Bixia Duan
- Jian Yue (ORCID: https://orcid.org/0009-0009-9868-0959)
- Lin Gan (ORCID: https://orcid.org/0000-0003-2160-5722)
- Qian Yang
- Hongda Li (ORCID: https://orcid.org/0000-0001-6754-5150)
- Ruochan Li
- Mengjia Shi
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Gaozhou People's Hospital (CN)
- Ludwig-Maximilians-Universität München (DE)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-12
- DOI
- https://doi.org/10.3389/fimmu.2024.1444222
- Citations
- 8
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 4.40