Deciphering the role of tryptophan metabolism-associated genes ECHS1 and ALDH2 in gastric cancer: implications for tumor immunity and personalized therapy
This research highlights the importance of ECHS1 and ALDH2 in GC progression and immune modulation, suggesting that targeted therapies focusing on these genes offer promising avenues for personalized immunotherapy in GC. These findings hold potential for improving patient survival and quality of life. Future studies on the NF-κB signaling pathway's role in this context are warranted to further elucidate the mechanisms underlying TMG-mediated immune modulation in GC.
Authors
- Weining Fan
- Shangke Huang (ORCID: https://orcid.org/0000-0002-9356-7588)
- Lexin Wang (ORCID: https://orcid.org/0000-0002-1136-063X)
- Ke Xu (ORCID: https://orcid.org/0000-0002-5465-3301)
- Binbin Wang (ORCID: https://orcid.org/0000-0003-1886-4993)
- Jie Liu (ORCID: https://orcid.org/0000-0003-3975-7978)
- Xue Zhou
- Yuheng Gu (ORCID: https://orcid.org/0009-0008-8145-0199)
- Yaping Miao (ORCID: https://orcid.org/0000-0001-5057-5273)
- Haisheng Yan
Institutions
- Chongqing University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
- First People's Hospital of Chongqing (CN)
- Dazhou Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-12
- DOI
- https://doi.org/10.3389/fimmu.2024.1460308
- Citations
- 16
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 4.56