A novel spherical GelMA-HAMA hydrogel encapsulating APET×2 polypeptide and CFIm25-targeting sgRNA for immune microenvironment modulation and nucleus pulposus regeneration in intervertebral discs
The study highlighted the crucial role of CFIm25 in IDD and introduced a promising therapeutic strategy using a porous spherical GelMA-HAMA hydrogel loaded with APET×2 polypeptide and sgRNA. This innovative approach offers new possibilities for treating degenerated intervertebral discs.
Authors
- Haimiti Abudouaini
- Yingguang Wang (ORCID: https://orcid.org/0000-0003-4629-3243)
- Peng Zou (ORCID: https://orcid.org/0000-0002-9798-5242)
- Yuan-Ting Zhao (ORCID: https://orcid.org/0000-0002-9822-0153)
- Shanxi Wang
- Jianbin Guan (ORCID: https://orcid.org/0000-0003-1491-9897)
- Xiaodong Wang (ORCID: https://orcid.org/0000-0001-7730-3710)
- Ding-Jun Hao (ORCID: https://orcid.org/0000-0002-0959-025X)
- Mengwei Li (ORCID: https://orcid.org/0009-0005-5503-9097)
- Xiaojun Yu (ORCID: https://orcid.org/0009-0004-7164-7562)
- Xiaofan Bai (ORCID: https://orcid.org/0009-0004-6796-3773)
- Leo Li (ORCID: https://orcid.org/0000-0001-5218-5463)
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1186/s12951-024-02783-z
- Citations
- 14
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 5.95
Funders
- National Natural Science Foundation of China