Branched-chain amino acids supplementation induces insulin resistance and pro-inflammatory macrophage polarization via INFGR1/JAK1/STAT1 signal pathway
The obesity mice model reveals the catabolism of BCAA was disrupted which will cause the accumulation of BCAA, and high-level BCAA will promote ATMs M1 polarization and increase the pro-inflammatory cytokines in adipose tissue which will cause the insulin resistance in further. Therefore, reducing the circulating level of BCAA can be a therapeutic strategy in obesity and insulin resistance patients.
Authors
- Heye Chen
- Huaying Huang (ORCID: https://orcid.org/0000-0002-3628-6480)
- X. C. Lou (ORCID: https://orcid.org/0009-0000-2746-0523)
- Yu Yao
Institutions
- Jinhua Central Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1186/s10020-024-00894-9
- Citations
- 25
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 9.67
Funders
- Jinhua Science and Technology Bureau