SIRT1-mediated deacetylation of FOXO3 enhances mitophagy and drives hormone resistance in endometrial cancer
This study reveals a novel molecular mechanism underlying the functional relevance of SIRT1 in regulating mitophagy and hormone resistance through the deacetylation of FOXO3 in EC, thereby providing valuable insights for new therapeutic strategies.
Authors
- Xiangpeng Xiong
- Wei Xue-hua
- Dongxian Peng
- Shufang Zhang (ORCID: https://orcid.org/0009-0000-7203-665X)
- Pingping Wang (ORCID: https://orcid.org/0000-0002-9861-3731)
Institutions
- Southern University of Science and Technology (CN)
- Jiangxi Maternal and Child Health Hospital (CN)
- Zhujiang Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1186/s10020-024-00915-7
- Citations
- 30
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 10.33