CXCR1 and CXCR2 are potential neutrophil extracellular trap-related treatment targets in ulcerative colitis: insights from Mendelian randomization, colocalization and transcriptomic analysis
Our study identified CXCR1/2 as candidate targets in UC among all NRGs through multi-method argumentation, providing new insights of the regulation mechanisms of NET formation in the pathogenesis of UC.
Authors
- Lin Jiang (ORCID: https://orcid.org/0000-0003-3408-3812)
- Yiyi Feng
- Yichuan Xv
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
- Yueyang Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-12
- DOI
- https://doi.org/10.3389/fimmu.2024.1425363
- Citations
- 15
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.61
Funders
- National Natural Science Foundation of China