Peripheral NK cell phenotypic alteration and dysfunctional state post hepatitis B subviral particles stimulation in CHB patients: evading immune surveillance
These findings suggest that HBVsvp may induce dysfunctional NK cell responses characterized by phenotypic imbalance with subsequent reduction in cytokine and cytotoxic levels, indicating HBVsvp immunosuppressive effect that compromises antiviral defense in CHB patients. These data enhance our understanding of NK cell interactions with HBsAg and highlight the potential for targeting CD94 inhibitory receptors to restore NK cell function as an immunotherapeutic approach. Further clinical research is needed to validate these observations and establish their utility as reliable biomarkers.
Authors
- Saeedah Musaed Almutairi (ORCID: https://orcid.org/0000-0002-0314-5761)
- Mohammed Aufy (ORCID: https://orcid.org/0000-0002-6693-4530)
- Mostafa A. Abdel-Maksoud (ORCID: https://orcid.org/0000-0002-6964-4846)
- Ebrahim Saied (ORCID: https://orcid.org/0000-0002-5622-7912)
- Reda A. Suef (ORCID: https://orcid.org/0000-0001-8080-1104)
- Mohamed Selim (ORCID: https://orcid.org/0000-0002-5539-7274)
- Mohamed M. S. Farag (ORCID: https://orcid.org/0000-0003-0581-8576)
- Mohamed T. Mansour
- Adel A. Mousa
Institutions
- University of Vienna (AT)
- Al-Azhar University (EG)
- King Saud University (SA)
- Armed Forces College of Medicine (EG)
- Children Cancer Hospital (EG)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-12
- DOI
- https://doi.org/10.3389/fimmu.2024.1427519
- Citations
- 3
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- King Saud University
- Universität Wien