Immune responses and transcription landscape of adults with the third dose of homologous and heterologous booster vaccines of COVID-19
This study demonstrated that inhalation/intramuscular injection of the Ad5-nCoV vaccine-mediated stronger humoral and cellular immune responses compared with the inactivated vaccine, and correlated significantly with innate immune function modules, supporting a heterologous booster immunization strategy.
Authors
- Yuqing Li (ORCID: https://orcid.org/0000-0002-2417-1424)
- Feiyu Wang (ORCID: https://orcid.org/0009-0009-1668-7760)
- Xiang Cao (ORCID: https://orcid.org/0000-0002-4573-8741)
- Lairun Jin (ORCID: https://orcid.org/0000-0003-1929-5198)
- Runjie Qi (ORCID: https://orcid.org/0009-0006-0419-190X)
- Hui Zheng (ORCID: https://orcid.org/0000-0002-7995-5808)
- Aihua Yao (ORCID: https://orcid.org/0000-0003-3144-6243)
- Fengcai Zhu (ORCID: https://orcid.org/0000-0002-1644-0006)
- Cuidan Li (ORCID: https://orcid.org/0000-0002-8430-1155)
- Xiaolong Li (ORCID: https://orcid.org/0000-0002-7317-2749)
- Li Chen (ORCID: https://orcid.org/0000-0002-9650-497X)
- Fei Chen (ORCID: https://orcid.org/0000-0002-6897-2725)
- Hu-Dachuan Jiang
- Wenqing Liu (ORCID: https://orcid.org/0009-0008-9780-8706)
- Jingxin Li (ORCID: https://orcid.org/0009-0001-7168-6287)
- Xiuyu Zheng
Institutions
- Chinese Academy of Sciences (CN)
- Beijing Institute of Genomics (CN)
- Jiangsu Provincial Center for Disease Control and Prevention (CN)
- CanSino (China) (CN)
- Southeast University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-12
- DOI
- https://doi.org/10.3389/fimmu.2024.1461419
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.78
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Major Research Plan
- Natural Science Foundation of Jiangsu Province for Distinguished Young Scholars