A multimodal approach identifies lactate as a central feature of right ventricular failure that is detectable in human plasma
In the failing RV with mutant BMPR2, lactate is produced by RV cardiomyocytes and may be secreted out, thereby increasing lactate in circulation. Lactate can potentially serve as a marker of RV dysfunction in PAH, which warrants investigation.
Authors
- Sheila Shay
- Jamey D. Young (ORCID: https://orcid.org/0000-0002-0871-1494)
- Eric D. Austin (ORCID: https://orcid.org/0000-0002-1709-9022)
- Megha Talati (ORCID: https://orcid.org/0000-0002-2892-8113)
- Niki Fortune (ORCID: https://orcid.org/0000-0002-0172-8672)
- Irina Trenary
- James West (ORCID: https://orcid.org/0000-0002-6004-0202)
- Anna R. Hemnes (ORCID: https://orcid.org/0000-0002-2755-5845)
- Evan Britain
- Katherine Simon (ORCID: https://orcid.org/0000-0001-9232-2653)
Institutions
- Vanderbilt University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2024-09-12
- DOI
- https://doi.org/10.3389/fmed.2024.1387195
- Citations
- 1
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- National Heart, Lung, and Blood Institute