Insulin-like growth factor-1 deficiency caused by hepatocellular adenoma leads to growth arrest, primary amenorrhea and metabolic syndrome: a case report and 4 years follow up
We provide evidence that liver-derived IGF-1 has a direct effect on skeletal and pubertal development, blood pressure, visceral adiposity and dyslipidemia independent of insulin resistance and obesity in the circumstance of undernutrition. Though rare, we propose the need to look into HCA cases for the existence of IGF-1 deficiency and its impact on metabolic derangement.
Authors
- Zhimin Huang (ORCID: https://orcid.org/0000-0001-9230-6039)
- Wanping Deng
- Yanbing Li (ORCID: https://orcid.org/0000-0003-3782-9210)
- Wenfang Chen (ORCID: https://orcid.org/0000-0003-3263-1096)
- Yuwen Li (ORCID: https://orcid.org/0009-0000-9359-8416)
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- BMC Endocrine Disorders
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1186/s12902-024-01716-z
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China