Maternal immunity shapes biomarkers of germinal center development in HIV‐exposed uninfected infants
GC immune pathways are perturbed in HEU newborns, but immune regulatory responses down regulate inflammation during early infancy, indicating a transient inflammatory effect. However, several GC biomarkers that may alter immune development remain perturbed.
Authors
- Maureen M. Goodenow (ORCID: https://orcid.org/0000-0002-4750-9627)
- Guglielmo M. Venturi
- Cliburn Chan (ORCID: https://orcid.org/0000-0001-5901-6806)
- Kristina De Paris (ORCID: https://orcid.org/0000-0001-5199-3004)
- John W. Sleasman (ORCID: https://orcid.org/0000-0003-0078-5867)
- Richard Barfield (ORCID: https://orcid.org/0000-0002-6276-7704)
- Julie J. Kim-Chang (ORCID: https://orcid.org/0000-0002-9799-9054)
- Li Yin (ORCID: https://orcid.org/0000-0002-3317-4133)
- Bernard M. Fischer (ORCID: https://orcid.org/0000-0001-8066-0516)
Institutions
- University of North Carolina at Chapel Hill (US)
- Duke University (US)
- National Institute of Allergy and Infectious Diseases (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-12
- DOI
- https://doi.org/10.3389/fimmu.2024.1443886
- Citations
- 10
- Primary Topic
- COVID-19 Impact on Reproduction
- Type
- article
- Field-Weighted Citation Impact
- 5.83
Funders
- International Maternal Pediatric Adolescent AIDS Clinical Trials Network
- National Institutes of Health
- Center for AIDS Research, Duke University
- Center for AIDS Research, University of Washington
- National Institute of Mental Health
- National Institute of Allergy and Infectious Diseases
- National Institute of Child Health and Human Development
- Office of AIDS Research
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NHLBI Division of Intramural Research