Identification of macrophage driver genes in fibrosis caused by different heart diseases based on omics integration
Using integrated single-cell transcriptomics, we identified the drivers of macrophage-mediated myocardial fibrosis in four heart diseases and confirmed the therapeutic effect of LVAD on improving HF with single-cell accuracy, providing novel insights into the diagnosis and treatment of myocardial fibrosis.
Authors
- Yang Wu (ORCID: https://orcid.org/0000-0002-7645-9817)
- Mengjia Li (ORCID: https://orcid.org/0000-0002-0336-5166)
- Yongzheng Zhang
- Lu-Feng Cheng (ORCID: https://orcid.org/0000-0002-5699-7482)
- Aerzu Mijiti
Institutions
- Xinjiang Medical University (CN)
- Xinjiang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1186/s12967-024-05624-7
- Citations
- 9
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 3.62