SIRT1 mediates the inflammatory response of macrophages and regulates the TIMP3/ADAM17 pathway in atherosclerosis
Our data suggest that SIRT1 deficiency may promote macrophage M1 polarization and regulate the TIMP3/ADAM17 pathway thus favoring atherosclerosis development, indicating an anti-atherosclerotic role of macrophage SIRT1.
Authors
- Ping Wei (ORCID: https://orcid.org/0009-0009-9034-2736)
- Yang Cao (ORCID: https://orcid.org/0000-0003-0152-639X)
- Meng Wang (ORCID: https://orcid.org/0000-0002-2375-8821)
- Liguo Zhang (ORCID: https://orcid.org/0000-0002-9795-0314)
- Dong Jia
- Dan Wang (ORCID: https://orcid.org/0000-0002-4688-8215)
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Experimental Cell Research
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1016/j.yexcr.2024.114253
- Citations
- 12
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 4.13