Digital Spatial Profiling identifies distinct patterns of immuno-oncology-related gene expression within oropharyngeal tumours in relation to HPV and p16 status
In terms of immune-oncology-related gene expression, discordant p16+/HPV- OPCs are much more closely aligned with p16-/HPV-OPCs and quite distinct from p16+/HPV+ tumours. This is consistent with previously described prognostic patterns (p16+/HPV+ >> p16+/HPV- > p16-/HPV-) and underlines the need for dual p16 and HPV testing to guide clinical decision making.
Authors
- Jill Brooks (ORCID: https://orcid.org/0000-0002-4955-5299)
- Hisham Mehanna (ORCID: https://orcid.org/0000-0002-5544-6224)
- Benjamin E. Willcox (ORCID: https://orcid.org/0000-0002-6113-2109)
- Janet Dunn (ORCID: https://orcid.org/0000-0001-7313-4446)
- Paul Nankivell (ORCID: https://orcid.org/0000-0003-4664-6117)
- Olivier Gevaert (ORCID: https://orcid.org/0000-0002-9965-5466)
- Yuanning Zheng (ORCID: https://orcid.org/0000-0002-0018-3252)
- Kelly J. Hunter
Institutions
- University of Warwick (GB)
- Stanford Medicine (US)
- County Hospital (GB)
- Hereford Health and Safety Group (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
- University of Birmingham (GB)
- Stanford University (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-09-12
- DOI
- https://doi.org/10.3389/fonc.2024.1428741
- Citations
- 4
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.32
Funders
- Cancer Research UK
- National Institute for Health and Care Research