DMDD, isolated from Averrhoa carambola L., ameliorates diabetic nephropathy by regulating endoplasmic reticulum stress-autophagy crosstalk
DMDD effectively inhibits excessive ERS and autophagy, thereby reducing renal cell apoptosis through the IRE1α pathway and Ca <sup>2+</sup> pathway.
Authors
- Renbin Huang (ORCID: https://orcid.org/0000-0002-1770-3795)
- Tao Liang (ORCID: https://orcid.org/0000-0003-1646-9666)
- Xiaojie Wei
- Yuxiang Wang (ORCID: https://orcid.org/0000-0002-5275-1709)
- Xiaohui Xu (ORCID: https://orcid.org/0000-0003-0205-0653)
- Jianmei Shi
- Jingxiao Xie
- Xixi Wang
Institutions
- Guangxi University (CN)
- Guangxi Medical University (CN)
- Guangxi University of Chinese Medicine (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1186/s13020-024-00993-z
- Citations
- 2
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangxi Province