Association of Serum Albumin Levels with Severity of Illness in Patients with Dengue Fever at Margalla Institute of Health Sciences Islamabad

Objective: To identify the association of serum albumin levels with the severity of illness in patients diagnosedwith dengue feverStudy Design: Cross-sectional study.Place and Duration of Study: The study was conducted at the Medicine Department of Margalla Institute ofHealth Sciences Islamabad, Pakistan from July 2022 to June, 2023.Methods: A total of 82 diagnosed cases of dengue fever were included in the study. All the baselineinvestigations were done including serum albumin at the time of diagnosis. The severity of the illness wasdetermined on the basis of platelet counts during the first week of illness. The association of various sociodemographic factors including albumin levels was determined with the severity of illness in the studyparticipants.Results: The mean age of study participants was 32.6±8.71years with 56 (68.3%) were males and 26 (31.7%)were females. Out of 82 dengue fever patients, 61 (74.4%) had mild illness while 21 (25.6%) had severe form ofdengue fever. 53 (64.6%) had normal albumin levels while 29 (35.4%) had deranged albumin levels. Pearson chi square analysis revealed that deranged albumin levels and wide pulse pressure had statistically significantrelationship with presence of severe dengue fever in our study participants (P-value<0.001).Conclusion: Patients with deranged albumin levels and wide pulse pressure during the course of illness weremore at risk of having severe dengue fever.