Specific cell subclusters of dental pulp stem cells respond to distinct pathogens through the ROS pathway
Our study analyzed the cellular and molecular properties of DPSCs infected by oral fungi and bacteria with single-cell RNA sequencing. A subcluster of DPSCs responded specifically to infections with different pathogens, activating the MAPK and NF-κB pathways to induce immune responses <i>via</i> the ROS pathway. This suggests novel treatment strategies for fungal infections.
Authors
- Sha Li (ORCID: https://orcid.org/0000-0002-2772-1698)
- Tiansong Xu (ORCID: https://orcid.org/0000-0003-4448-5831)
- Xueying Li
- Xiaoying Zou (ORCID: https://orcid.org/0000-0002-1841-5779)
- Liqi Zhang (ORCID: https://orcid.org/0000-0002-6421-680X)
- Yifei Zhang (ORCID: https://orcid.org/0000-0003-2906-8159)
- Wen Zhang (ORCID: https://orcid.org/0000-0001-5166-0736)
- Fangfang Chen (ORCID: https://orcid.org/0000-0002-0854-1667)
- Lin Yue
- Murong Li (ORCID: https://orcid.org/0009-0005-3659-8440)
- Ye Lin (ORCID: https://orcid.org/0000-0002-0750-8996)
- Yangjia Liu
Institutions
- Peking University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- National Clinical Research (US)
- Peking University International Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-09-12
- DOI
- https://doi.org/10.3389/fcimb.2024.1452124
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- Ministry of Science and Technology of the People's Republic of China