High Burden of Ileus and Pneumonia in Clozapine-Treated Individuals With Schizophrenia: A Finnish 25-Year Follow-Up Register Study
Clozapine-induced ileus and pneumonia were notably more frequent than has previously been reported and were associated with increased mortality. Two <i>CYP</i> genes influenced pneumonia risk. Pneumonia and ileus call for improved utilization of available preventive measures.
Authors
- Paavo Häppölä (ORCID: https://orcid.org/0000-0002-8502-0582)
- Juulia Partanen (ORCID: https://orcid.org/0000-0002-4012-808X)
- Antti J. Tanskanen (ORCID: https://orcid.org/0000-0002-3795-3126)
- Jukka Koskela (ORCID: https://orcid.org/0000-0002-0154-7222)
- Heidi T. Taipale (ORCID: https://orcid.org/0000-0002-3281-934X)
- Ari Ahola‐Olli (ORCID: https://orcid.org/0000-0002-4451-3487)
- Jarmo Hietala (ORCID: https://orcid.org/0000-0002-3179-6780)
- Susanna Maria Rask
- Willehard Haaki (ORCID: https://orcid.org/0000-0002-2850-7650)
- Jari Tiihonen (ORCID: https://orcid.org/0000-0002-0400-6798)
- Olli Kampman (ORCID: https://orcid.org/0000-0001-6891-2266)
- Aarno V. Palotie (ORCID: https://orcid.org/0000-0002-2527-5874)
- Anders Kämpe (ORCID: https://orcid.org/0000-0002-1829-3855)
- Markku Lähteenvuo (ORCID: https://orcid.org/0000-0002-7244-145X)
- Mark J. Daly (ORCID: https://orcid.org/0000-0002-0949-8752)
- Samuli Ripatti
- Anni Hellsten
Institutions
- Institute for Molecular Medicine Finland (FI)
Publication Details
- Journal
- American Journal of Psychiatry
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1176/appi.ajp.20230744
- Citations
- 32
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 12.34