A mysterious malignant mixed germ cell tumor with successful term pregnancy- an enigma

Ovarian germ cell tumors (GCT) comprise 15-20% of ovarian neoplasms of which 3-5% are malignant. The incidence of ovarian germ cell tumor in pregnancy is low and malignant GCT account for 18-26%. Among the malignant GCTs, Dysgerminoma is the most common tumor followed by Yolk sac tumor. An interesting case of Malignant mixed germ cell tumor in 23-year old pregnant lady who had a full term normal delivery is reported. The patient remained asymptomatic till term pregnancy. Routine ultrasonography misdiagnosed as swelling as a fibroid in early 8 week of gestation, which progressed to a size 13x10cm at 32 week gestation. At 38 weeks, patient underwent LSCS along with resection of the tumor which mimicked as fibroid. On histopathological examination along with Immunohistochemistry, it was reported as malignant mixed GCT with Dysgerminoma (85%) and Yolk sac tumor (15%) components. Misdiagnosis is not uncommon in pregnancy; hence multidisciplinary approach can help in arriving at an earlier and correct diagnosis which further helps in early and appropriate treatment thereby increasing the survival rates. This case is reported for its rare presentation mimicking as a fibroid radiologically and histopathological examination reported as Malignant Mixed GCT and was associated with a successful term viable pregnancy.

Authors

Institutions

Publication Details

Journal
Indian Journal of Pathology and Oncology
Published
2024-09-12
DOI
https://doi.org/10.18231/j.ijpo.2024.064
Primary Topic
Testicular diseases and treatments
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

A mysterious malignant mixed germ cell tumor with successful term pregnancy- an enigma

K Abiramavalli, Veeraraghavan Gurusamy, S Brihadisvarar, V Vanitha et al.
Indian Journal of Pathology and Oncology
Testicular diseases and treatments
article

A mysterious malignant mixed germ cell tumor with successful term pregnancy- an enigma

K Abiramavalli, Veeraraghavan Gurusamy, S Brihadisvarar, V Vanitha, Jeyalakshmi Devi Namasivayam, Lakshmi Piriya P
article en

Abstract

Ovarian germ cell tumors (GCT) comprise 15-20% of ovarian neoplasms of which 3-5% are malignant. The incidence of ovarian germ cell tumor in pregnancy is low and malignant GCT account for 18-26%. Among the malignant GCTs, Dysgerminoma is the most common tumor followed by Yolk sac tumor. An interesting case of Malignant mixed germ cell tumor in 23-year old pregnant lady who had a full term normal delivery is reported. The patient remained asymptomatic till term pregnancy. Routine ultrasonography misdiagnosed as swelling as a fibroid in early 8 week of gestation, which progressed to a size 13x10cm at 32 week gestation. At 38 weeks, patient underwent LSCS along with resection of the tumor which mimicked as fibroid. On histopathological examination along with Immunohistochemistry, it was reported as malignant mixed GCT with Dysgerminoma (85%) and Yolk sac tumor (15%) components. Misdiagnosis is not uncommon in pregnancy; hence multidisciplinary approach can help in arriving at an earlier and correct diagnosis which further helps in early and appropriate treatment thereby increasing the survival rates. This case is reported for its rare presentation mimicking as a fibroid radiologically and histopathological examination reported as Malignant Mixed GCT and was associated with a successful term viable pregnancy.

Indian Journal of Pathology and OncologyVol. 11(3)
Government Kilpauk Medical College (IN), Stanley Medical College (IN), Government Medical College and Hospital (IN), Government Medical College (IN)
Good health and well-being
Openalex Percentile: Top 72%
Testicular diseases and treatments
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

A mysterious malignant mixed germ cell tumor with successful term pregnancy- an enigma — K Abiramavalli, Veeraraghavan Gurusamy, et al. · Indian Journal of Pathology and Oncology (2024) | TGRS Research Map | TGRS