Economic evaluation of extended panel analysis in cancer patients with historical NHS diagnostic germline genetic testing – A modeling study based on real-world data
Where existing NGS data for cancer susceptibility genes is stored to diagnostic standard in UK laboratories, this study suggests it is cost-effective to analyze, report and clinically manage patients and relatives by extended analysis to an 8-gene panel compared to the historical genetic testing.
Authors
- Stephen Morris (ORCID: https://orcid.org/0000-0002-5828-3563)
- Thomas Linton-Willoughby
- Marc Tischkowitz (ORCID: https://orcid.org/0000-0002-7880-0628)
- John Rennie Short (ORCID: https://orcid.org/0000-0001-7141-6626)
- Katie M.G. Snape (ORCID: https://orcid.org/0000-0002-1739-7986)
- Qin Xi (ORCID: https://orcid.org/0000-0002-9712-4688)
- Rahul Patel (ORCID: https://orcid.org/0000-0003-1175-0635)
Institutions
- University of Cambridge (GB)
- St George’s University Hospitals NHS Foundation Trust (GB)
- National Institute for Health and Care Research (GB)
- Primary Health Care (QA)
Publication Details
- Journal
- European Journal of Medical Genetics
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1016/j.ejmg.2024.104969
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00