Mitochondrial sequence variants: testing imputation accuracy and their association with dairy cattle milk traits
The accuracy of imputation of mitochondrial genotypes from the SNP panel to sequence was generally low. The Beagle DR2 statistic enabled selection of sites imputed with higher empirical accuracy. We recommend building larger reference populations with mitochondrial sequence to improve the accuracy of imputing less common variants and ensuring that SNP panels include common variants in the D-loop region.
Authors
- Coralie M. Reich
- Jigme Dorji (ORCID: https://orcid.org/0000-0003-4057-8918)
- Iona M. MacLeod
- Hans D. Daetwyler (ORCID: https://orcid.org/0000-0002-3018-3640)
- Christy J. Vander-Jagt
- Tuan V. Nguyen (ORCID: https://orcid.org/0000-0003-0415-0623)
- Amanda J. Chamberlain
Institutions
- Commonwealth Scientific and Industrial Research Organisation (AU)
- La Trobe University (AU)
- Agriculture Victoria (AU)
- Federal Scientific Center for Vegetable Growing (RU)
- AgriBio (AU)
Publication Details
- Journal
- Genetics Selection Evolution
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1186/s12711-024-00931-5
- Citations
- 2
- Primary Topic
- Genetic and phenotypic traits in livestock
- Type
- article
- Field-Weighted Citation Impact
- 1.10
Funders
- Gardiner Foundation
- Agriculture Victoria