Capsaicin mitigates ventilator-induced lung injury by suppressing ferroptosis and maintaining mitochondrial redox homeostasis through SIRT3-dependent mechanisms
The outcomes showed that CAP alleviated ferroptosis in VILI via improving the activity of SITR3 to suppressing mitochondrial oxidative damage and maintaining mitochondrial redox homeostasis, illustrating its possibility as a novel therapeutic goal for VILI.
Authors
- Liming Cen (ORCID: https://orcid.org/0000-0001-5380-238X)
- Bijun Luo
- Fei Lin (ORCID: https://orcid.org/0000-0002-7497-6159)
- Linghui Pan (ORCID: https://orcid.org/0000-0001-7683-670X)
- Maoyao Ling
- Ye Liu (ORCID: https://orcid.org/0000-0001-5827-5240)
- Jinyuan Lin
- Zhaokun Hu
- Huajin Ou
Institutions
- Guangxi Medical University (CN)
- Health Commission of Anhui Province (CN)
- 303 Hospital of People's Liberation Army (CN)
- Cooperative Research Centre for Tissue Growth and Repair (AU)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1186/s10020-024-00910-y
- Citations
- 14
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- National Natural Science Foundation of China
- Youth Science Foundation of Guangxi Medical University