Insights into epithelial-mesenchymal transition from cystic fibrosis rat models
Our findings show the first evidence of upregulated EMT pathways in the lungs and airway cells of any CF animal model. Differences in the regulation of the EMT genes and proteins in the Phe508del and CFTR-KO cells suggest that the signalling pathways underlying EMT are CFTR mutation dependent.
Authors
- Bernadette Boog
- David Parsons (ORCID: https://orcid.org/0000-0003-1746-3290)
- Martin Donnelley (ORCID: https://orcid.org/0000-0002-5320-7756)
- Alexandra McCarron (ORCID: https://orcid.org/0000-0002-6045-3998)
- Nicole Reyne (ORCID: https://orcid.org/0000-0002-3487-0827)
- Nathan Rout-Pitt (ORCID: https://orcid.org/0000-0002-4003-4454)
Institutions
- Women's and Children's Hospital (AU)
- The University of Adelaide (AU)
Publication Details
- Journal
- Journal of Cystic Fibrosis
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1016/j.jcf.2024.09.003
- Citations
- 5
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Cystic Fibrosis Foundation