Informing Decision-making for Transected Margin Reresection in Intraductal Papillary Mucinous Neoplasm-derived PDAC
In IPMN-derived PDAC, normal epithelium or low-grade dysplasia at the neck have similar outcomes while pancreatic neck margins with high-grade dysplasia or invasive cancer are associated with poorer outcomes. Conversion of a high-risk to low-risk margin after intraoperative frozen section is associated with survival benefit and should be performed when feasible.
Authors
- Greg D. Sacks (ORCID: https://orcid.org/0000-0003-1205-6477)
- Beat Peter Müller-Stich (ORCID: https://orcid.org/0000-0002-8552-8538)
- Hjalmar C. van Santvoort (ORCID: https://orcid.org/0009-0007-1218-2883)
- Marc G. Besselink (ORCID: https://orcid.org/0000-0003-2650-9350)
- Adrian T. Billeter (ORCID: https://orcid.org/0000-0001-8724-4793)
- Markus Wolfgang Büchler (ORCID: https://orcid.org/0000-0002-3666-5675)
- Benedict Kinny‐Köster (ORCID: https://orcid.org/0009-0003-7040-9725)
- Ingmar F. Rompen (ORCID: https://orcid.org/0000-0002-0257-1654)
- Joseph R. Habib (ORCID: https://orcid.org/0000-0003-3445-2278)
- Brady A. Campbell (ORCID: https://orcid.org/0000-0002-0792-6928)
- Lois A. Daamen (ORCID: https://orcid.org/0000-0001-9227-7178)
- I Quintus Molenaar
- Jing He (ORCID: https://orcid.org/0000-0002-1954-2892)
- P. Andel (ORCID: https://orcid.org/0009-0006-9341-9282)
- Ammar A. Javed (ORCID: https://orcid.org/0000-0002-5463-5250)
- Christopher L. Wolfgang (ORCID: https://orcid.org/0000-0002-8717-0373)
- Martin Loos
Institutions
- Champalimaud Foundation (PT)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Medical Center Utrecht (NL)
- NYU Langone Health (US)
- St. Antonius Ziekenhuis (NL)
- Johns Hopkins Hospital (US)
- Amsterdam University Medical Centers (NL)
- Cancer Center Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Annals of Surgery
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1097/sla.0000000000006532
- Citations
- 6
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Institutes of Health