Navigating the diagnostic gray zone: a challenging case of pancreatic high-grade neuroendocrine neoplasm

This case highlights the diagnostic complexities of distinguishing G3 PanNET and PanNEC even with the support of ancillary immunohistochemical and molecular studies. In addition, such cases raise the possibility that G3 PanNET and PanNEC may lie on a spectrum of disease with potential biological overlap.

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Publication Details

Journal
Diagnostic Pathology
Published
2024-09-12
DOI
https://doi.org/10.1186/s13000-024-01546-6
Citations
4
Primary Topic
Neuroendocrine Tumor Research Advances
Type
article
Field-Weighted Citation Impact
1.55
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article

Navigating the diagnostic gray zone: a challenging case of pancreatic high-grade neuroendocrine neoplasm

Mingjuan Lisa Zhang, Brooke Mullen, Priscila Dias Goncalves, Albert Sy
4 citations
Diagnostic Pathology
Neuroendocrine Tumor Research Advances
1.55
article

Navigating the diagnostic gray zone: a challenging case of pancreatic high-grade neuroendocrine neoplasm

Mingjuan Lisa Zhang, Brooke Mullen, Priscila Dias Goncalves, Albert Sy
article en
4 citations

Abstract

This case highlights the diagnostic complexities of distinguishing G3 PanNET and PanNEC even with the support of ancillary immunohistochemical and molecular studies. In addition, such cases raise the possibility that G3 PanNET and PanNEC may lie on a spectrum of disease with potential biological overlap.

Diagnostic PathologyVol. 19(1)
Harvard University (US), Massachusetts General Hospital (US)
Openalex Percentile: Top 16%
Neuroendocrine Tumor Research Advances
1.55
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