Enhancement of Intracellular Cholesterol Efflux in Chondrocytes Leading to Alleviation of Osteoarthritis Progression
Our results suggest that restoration of cholesterol homeostasis to a normal state through administration of fenofibrate or AIBP overexpression, both of which induce cholesterol efflux, offers an effective therapeutic option for patients with OA.
Authors
- Seung‐Hee Kwon
- Jang‐Soo Chun (ORCID: https://orcid.org/0000-0003-2910-181X)
- Ki‐Ho Chung (ORCID: https://orcid.org/0000-0002-0395-2344)
- Yun Hyun Huh (ORCID: https://orcid.org/0000-0002-8507-8602)
- Thanh‐Tam Tran
- Ka Hyon Park (ORCID: https://orcid.org/0000-0002-3045-8288)
- Je‐Hwang Ryu (ORCID: https://orcid.org/0000-0002-8708-8943)
- Jong‐Keun Seon (ORCID: https://orcid.org/0000-0002-6920-5659)
- Jeong‐Tae Koh (ORCID: https://orcid.org/0000-0001-6279-6487)
- Sun Young Lee (ORCID: https://orcid.org/0000-0002-6928-7471)
- Su Jin Kim (ORCID: https://orcid.org/0000-0003-3816-9664)
- Hyun Ah Kim (ORCID: https://orcid.org/0000-0002-3175-9218)
- Gyuseok Lee (ORCID: https://orcid.org/0000-0002-5258-9166)
- Jiye Yang
Institutions
- Chonnam National University (KR)
- Gwangju Institute of Science and Technology (KR)
- Sacred Heart Hospital (US)
- Chonnam National University Hwasun Hospital (KR)
- Hallym University Sacred Heart Hospital (KR)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1002/art.42984
- Citations
- 14
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea