Ethanol with thioacetamide murine model of alcoholic liver disease identifies hepatic pathways as targets for the human disease
Using an ethanol-thioacetamide combination in mice results in a faster establishment of AAH with fibrosis than previously known models. Differential protein expression strongly correlates with pathways found altered in human AAH, thus making the model mimic human disease better than other known models., respectively. Thioacetamide (TAA) was administered to enhance liver fibrosis and mimic human AAH.
Authors
- Sudrishti Chaudhary (ORCID: https://orcid.org/0000-0002-0150-6308)
- Shiv Kumar Sarin (ORCID: https://orcid.org/0000-0002-0544-5610)
- Jaswinder Singh Maras (ORCID: https://orcid.org/0000-0003-3938-362X)
- Nishu Choudhary (ORCID: https://orcid.org/0000-0002-8571-6993)
- Shvetank Sharma (ORCID: https://orcid.org/0000-0001-7139-2011)
- Anupama Kumari (ORCID: https://orcid.org/0000-0003-0579-5706)
- Ashi Mittal
- Archana Rastogi
- Guresh Kumar
Institutions
- Institute of Liver and Biliary Sciences (IN)
Publication Details
- Journal
- Annals of Hepatology
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1016/j.aohep.2024.101565
- Citations
- 2
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.85