Plasminogen - safe for treatment of chronic tympanic membrane perforation: a phase 1 randomized, placebo-controlled study

This pilot study suggests that plasminogen injections close to the tympanic membrane as treatment for chronic tympanic membrane injections are safe and feasible, encouraging further dose-escalating studies.

Authors

Bo Tideholm (ORCID: https://orcid.org/0000-0002-5530-7662)
Cecilia Engmér Berglin (ORCID: https://orcid.org/0009-0003-1986-3818)
Elnaz Sepehri (ORCID: https://orcid.org/0000-0002-5525-2497)
Sten Hellström

Institutions

Karolinska University Hospital (SE)
Karolinska Institutet (SE)

Publication Details

Journal: Acta Oto-Laryngologica
Published: 2024-08-12
DOI: https://doi.org/10.1080/00016489.2024.2396488
Citations: 2
Primary Topic: Ear Surgery and Otitis Media
Type: article
Field-Weighted Citation Impact: 1.16

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article

Plasminogen - safe for treatment of chronic tympanic membrane perforation: a phase 1 randomized, placebo-controlled study

Bo Tideholm, Cecilia Engmér Berglin, Elnaz Sepehri, Sten Hellström

Aug 12, 2024

2 citations

Acta Oto-Laryngologica

Ear Surgery and Otitis Media

1.16

article

Plasminogen - safe for treatment of chronic tympanic membrane perforation: a phase 1 randomized, placebo-controlled study

Bo Tideholm, Cecilia Engmér Berglin, Elnaz Sepehri, Sten Hellström

August 12, 2024article en

2 citations

Abstract

Acta Oto-LaryngologicaVol. 144(7-8)

Karolinska University Hospital (SE), Karolinska Institutet (SE)

Good health and well-being

Openalex Percentile: Top 21%

Ear Surgery and Otitis Media

1.16

DOI Source OpenAlex

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Plasminogen - safe for treatment of chronic tympanic membrane perforation: a phase 1 randomized, placebo-controlled study — Bo Tideholm, Cecilia Engmér Berglin, et al. · Acta Oto-Laryngologica (2024) | TGRS Research Map | TGRS