ALDH1L2 drives HCC progression through TAM polarization
This research highlights that ALDH1L2 could serve as a predictive and prognostic marker in HCC. We found that a positive feedback loop between ALDH1L2 and NRF2 promotes HCC progression by activating the IL-6/Jak2/STAT3 signaling axis and tumor-associated macrophage polarization. In addition, we found that ALDH1L2 knockdown enhances the anti-HCC effect of sorafenib.
Authors
- Lili Meng (ORCID: https://orcid.org/0000-0002-1541-886X)
- Hua Tian (ORCID: https://orcid.org/0000-0002-2316-1953)
- Xi‐Dai Long (ORCID: https://orcid.org/0000-0003-0960-0689)
- Qingqing Zhou (ORCID: https://orcid.org/0000-0002-6019-4228)
- Chi Zhang (ORCID: https://orcid.org/0000-0003-1408-0841)
- Jiayi Chen (ORCID: https://orcid.org/0000-0001-6053-9444)
- Jun Wu (ORCID: https://orcid.org/0000-0002-0678-3435)
- Chao Ge (ORCID: https://orcid.org/0000-0002-5976-3462)
- Yue Yang (ORCID: https://orcid.org/0000-0001-5425-8216)
- Qinqin Long (ORCID: https://orcid.org/0000-0001-9891-1651)
- Wei Tian
- Yu-Ting Su
- Jiajun Li (ORCID: https://orcid.org/0009-0001-9227-9197)
Institutions
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Renji Hospital (CN)
- Shanghai Cancer Institute (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- Shanghai First People's Hospital (CN)
- Baise University (CN)
Publication Details
- Journal
- JHEP Reports
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1016/j.jhepr.2024.101217
- Citations
- 8
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 2.61
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangxi Province